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Haloperidol CAS № 52-86-8
Haloperidol marketed under the trade name Haldol among others, is a typical antipsychotic medication. Haloperidol is used in the treatment of schizophrenia, tics in Tourette syndrome, mania in bipolar disorder, nausea and vomiting, delirium, agitation, acute psychosis, and hallucinations in alcohol withdrawal.
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Haloperidol
Haloperidol, marketed under the trade name Haldol among others, is a typical antipsychotic medication. Haloperidol is used in the treatment of schizophrenia, tics in Tourette syndrome, mania in bipolar disorder, nausea and vomiting, delirium, agitation, acute psychosis, and hallucinations in alcohol withdrawal.
Haloperidol binds preferentially to D2 and α1 receptors at low dose (ED50 = 0.13 and 0.42 mg/kg, respectively), and 5-HT2 receptors at a higher dose (ED50 = 2.6 mg/kg). Given that antagonism of D2 receptors is more beneficial on the positive symptoms of schizophrenia and antagonism of 5-HT2 receptors on the negative symptoms, this characteristic underlies haloperidol's greater effect on delusions, hallucinations and other manifestations of psychosis. Haloperidol's negligible affinity for histamine H1 receptors and muscarinic M1 acetylcholine receptors yields an antipsychotic with a lower incidence of sedation, weight gain,and orthostatic hypertension.
Formal Name
| 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone | |
| CAS Number | 52-86-8 |
| Synonyms |
|
| Molecular Formula | C21H23ClFNO2 |
| Formula Weight | 375.9 |
| Purity | ≥99% [Current batch 99.2%] |
| Formulation | A crystalline solid |
 |
Solubility (25°C)
| In vitro | DMSO | 75 mg/mL (199.54 mM) |
|---|---|---|
| Ethanol | 8 mg/mL (21.28 mM) | |
| Water | <1 mg/mL | |
| In vivo | 10% DMSO+corn oil |
5mg/mL |
USAGE: For Research Use Only! Not For Use in Humans!