NSI-189 is a novel neurogenic nootropic anti-depressant agent that has successfully undergone Phase 1a clinical trials for depression with 41 healthy volunteers, as well finished Phase 1b trials with 26 depressed patients. In vivo healthy mice testing revealed a remarkable 20% increase in hippocampal volume. Indications for neurogenic and antidepressant...
Glutamatergic NMDA receptor antagonist
Fasoracetam (a.k.a. NS-105 and LAM-105) is a potent HACU-inhibiting, cAMP-modulating, GABAB receptor upregulating/antagonizing, mGluR-modulating, non-monoaminergic anti-depressant nootropic. Research Indications: Nootropic, Antidepressant, Anxiolytic, ADHD Research, Addiction Cessation, GABAergics/Benzodiazepine Research
J147 has displayed neurotrophic, neuroprotective, neuroanti-inflammatory, nootropic and LTP-enhancing activity. It is a potent, orally active hybrid of curcumin and cyclohexyl-bisphenol A. J147 research demonstrates an ability to reduce soluble Aβ40 and Aβ42 levels. Indicated for neurogenic, antidepressant, anti-psychoneurodysfunctionality, anxiolytic...
9-Methyl-9B-Carboline is a dopaminergic enhancer that up-regulates, differentiates and protects dopaminergic neurons, dendrities and synapses, especially in the substantia nigra of the midbrain and in the hippocampus, as well as enhances dopamine synthesis. Research Indications: Dopaminergic Research, Addiction Research, Neuroprotection Research
Optimized Analogue - Eugeroic Nootropic Research *** EUGERAFINIL-OA (TLR-203) is a TLR-OA compound intended for research into optimization of agents toward the goal of an optimized eugeroic to best foster the promotion of effects that include enhanced vigilance, wakefulness, energy, and focus.
SENOLYTIXTM is an optimized combination of Dasatinib(D) and Quercetin(Q) based off the landmark science into practically applicable senolytics. SENOLYTIXTM offers the most optimized formulation for progressive research into the paradigm of senolytic agents to date and to afford progress within research against the ravages of aging. Research Indications:...
Emoxypine (a.k.a. Mexidol, Mexifin - specifically within its succinate salt form), is an unusually pleiotropic anti-oxidant with structural resemblance to pyridoxine with several research indications. Indications include anxiolytic, nootropic, neuroprotective, antidepressant, anti-hypoxic, and anti-addictive research.
Guanfacine is a nootropic, sympatholytic, α2A receptor agonist that has been indicated for ADHD and OCD symptomatologies. Guanfacine as well has demonstrated an indication for reduction of opioid withdrawals and detoxification of recreational substances. Guanfacine promotes increased secretion of growth hormone.
Optimized Extract - Addiction Cessation Research Scientifically Engineered Proprietary Optimized Extract Formulation Acting Upon Resetting Addiction Targeted Pathways and Counteracting Hyper-Psychoneurodysfunctional States. Indication for anti-addiction, anti-withdrawal, antidepressant, anxiolytic, neurogenic, anti-obesity, mood disorder treatment, and...
Rasagiline is a novel, highly potent, irreversible monamine oxidase B inhibitor (selective), which is related to Selegiline. It has also been observed to exhibit neuroprotective, neurotrophic, and mitochondriaprotective actions. Rasagiline demonstrates an ability to promote increased levels of NGF, GDNF. and BDNF proteins and expression.
GHK/GHK-Cu tripeptides display marked anti-aging and restorative efficacy within many physiological aspects. Indications for Anti-Aging Research.
Acetyl Epitalon (syn. Acetyl Epithalon, N-Acetyl-Epitalon, Ac Epi) Epitalon has demonstrated in studies to have notable positive efficacy upon telomeres and aging. The acetyl variant, Acetyl Epitalon, provides far superior metabolic stability and pharmacodynamics.
Optimized Extract - Cannabinoid Receptor Modulation/Endocannabinoid Modulation Research CBRM-OX is a Scientifically Engineered Cannabinoid Receptor/Endocannabinoid Modulator (CB1R/CB2R agonist dominant) Extract.~Indications for anxiolytic, analgesic, antidepressant, myorelaxant, antiemetic, neuroprotective, antiepileptic, immunomodulatory,...
COPE-OX Optimized Clean Opioid Xtract is a proprietary, novel extract that modulates the opioid system for optimized analgesic and mood-elevating benefits largely sans the typical adverse effects associated with opioids. Research Indications: Analgesia Research, Antidepressant Research, Anxiolytic Research
Agomelatine is a melatonergic agonist promoting fairly rapid acting antidepressant effects. It is particularly effective within paradigms of poor sleep quality and circadian rhythm dysregulation; benefit to anxiolytic and stress-response tone. Indications for antidepressant (MDD), anxiolytic, and somnolescent research, as well as potential indications...
Optimized Extract - Optimized Libidogenic Research Scientifically Engineered Selective Melanocortin-4 Receptor (MC4R) Activator Extract Indicated for libido depression, erectile dysfunction, pro-sexual functionality research
ORPA-ULTRA is a refined variation on th ORPA-OX platform to create a stronger Optimized Xtract with similar qualities. ORPA-ULTRA is a moderate partial agonist at the MOR and DOR that demonstrates a clean efficacy free from adverse effects, tolerance, and addiction potential. Research Indications: Analgesia, Opioidergic, Antidepressant/Mood Elevation,...
KORX-OX - Kappa Opioid Receptor Antagonist Optimized Xtract First-In-Class orally bioavailable, long-acting kappa-opioid receptor (KOR) antagonist herbal extract. Activates the c-Jun pathway to 'corrupt' the KOR akin to that of the class of synthetic KOR antagonists. Research Indications: Opioidergic Research, Antidepressant Research, Anxiolytic...
HCBT-OX Herbal Cerebrotrophic Optimized Extract - HCBT-OX fosters proliferation and development of neurons, axon (myelination), dendrites, and synapses in the cerebral cortex and hippocampus. Indications for neurogenic, antidepressant, anxiolytic, neuroregenerative (Alzheimer's Disease, et al.) , and anti-nueropsychodysfunction research.
SBZD-OX Guided Scientifically Engineered Selective BZD Modulator Extract Indications for anxiolytic research.
Flumazenil is a potent benzodiazepine receptor antagonist. Flumazenil administration has been demonstrated to have efficacy to reverse benzodiazepine tolerance and create a facilitation of rapidly alleviating PAWS (Post-Acute Withdrawal Syndrome). Research Indications: Addiction Research, GABAergic/Benzodiazepine Research, Anxiolytic Research
GLYX-OA aka GLYXtract is a Proprietary Bio-Guided Fraction Optimized First-In-Class NMDA Glycine-Site Specific Functional Antagonist Xtract with potent antidepressant, neurogenic, and cognition enhancement efficacy that displays no adverse effects. Research Indications: Antidepressant, Analgesic, Procognitive, Neurogenic, Anti-inflammatory, Anti-Aging
Optimized Extract - Analgesic Optimization Research Scientifically Engineered Selective Opioid Receptor Modulation Extract designed and developed for optimized analgesia with superior therapeutic index with markedly lower tolerance and adverse effects as classical opiate analgesics. Research Indications: Analgesic, Antidepressant, Anxiolytic research
Optimized Extract - Optimized Fear Extinction Research HDAC-OX Scientifically Engineered HDAC Class I Inhibitor (HDAC-C1I) Extract Indications for anxiolytic, fear extinction, analgesia, and antidepressant research (potental for anti-aging research).
NEUMYO-OA Ultra-Potent Myostatin & GDF11 Direct Inhibitor is an Optimized Antibody that has high efficacy to antagonize GDF11 ('Neurostatin™') and GDF8 (myostatin) to foster highly significant anti-catabolic/anabolic and myotrophic effects upon skeletal muscle. Research Indications: Anabolic/Myotrophic Research, Anti-Cachexic/Anti-catabolic...
DONA-OX: Dual Opioidergic Novel Analgesic Optimized Xtract Scientifically Engineered, Wholly Novel, Herbal-Based Extract Matrix researched and developed by TeamTLR Science is a unique “dual opioidergic” activating extract with solid functional agonist bias at the MOR and OLR-1r receptors for enhanced analgesic efficacy. Research Indications:...
Isoxazole-9 (ISX-9) is a neurogenic agent that promotes neurogenesis in vivo through the mechanisms of enhancing the proliferation and differentiation of hippocampal subgranular zone neuroblasts with resultant effects upon enhancing memory and potential antidepressant effects. Indications for neurogenic and antidepressant research.
ENKI-OX Scientifically Engineered Enkephalinase Inhibitor -- Indications for analgesia, antidepressant, anxiolytic research, and anti-addiction research.
Noopepteine-OA (TLR-211) is an optimized analogue based off the Noopept dipeptide platform to encompass optimization toward the goal to foster highly enhanced focus, concentration, energy, and cognition. A marked synergy and enhanced therapeutic index and efficacy is demonstrated with classes of PDE inhibitors. Indications for nootropic, ADHD,...
N-Palmitoylethanolamide displays potent efficacy within relieving pain, depression, anxiety, and other debilitating conditions. Research Indications: Analgesic Research (Neuropathic, Chronic, Anti-Inflammatory), Antidepressant Research, Anxiolytic Research, Neurogenic/Neuroprotectant Research, Anti-Cancer Research
SNRB-OX is a proprietary Optimized Xtract Scientifically Engineered Selective NMDA Receptor Subunit 2B (NR2B) Low-Efficacy Weak Partial Agonist with Functional Antagonist activity. Research Indications: antidepressant, anxiolytic, neuroprotectant, neuroregenerative, and congnition enhancement research. Supplied in solution
Rimonabant is a potent CB1R inverse agonist demonstrating significant anti-obesity and anti-addiction effects, as well as calorie restriction mimetic (CRM) anti-aging capacities. Research Indications: Anti-obesity, Anti-aging, and Anti-addiction (smoking cessation, et al.) research.
OPIO-OX Opioid System Enhancer Optimized Xtract Formulation Targets multiple opioidergic pathways to optimize the opioidergic system for enhanced beneficial effects within goals of analgesic-sparing, tolerance sparing, and adverse effects sparing outcomes. Research Indications: Opioidergic Research, Analgesia Research, Addiction Research
β-ANDROSTENETRIOL-OA (TLR-108) is an optimized analogue intended for research into optimization of agents toward the goal of an optimized adjunct agent to foster anxiolysis, cortisol reduction, and reduction of stress induced symptomatologies devoid of any adverse effects. Indicated for anxiolytic/stress and anti-obesity research.
URB597 is a potent, orally bioavailable FAAH inhibitor. URB597 inhibits hydrolysis of FAAH metabolized substrates within the endocannabinoid and related systems invoking a parallel increase in brain anandamide, OEA, and PEA. Efficacy on parameters of mood, anxiety, and analgesia with no demonstration of adverse effects.
Nicotinamide Adenine Dinucleotide (NAD+) NAD+ demonstrates highly significant elevated blood plasma levels and has capacity to cross the plasmalemma memebrane and penetrate the blood brain barrier when administered via sublingual and intranasal route in animal models. Indications for anti-aging research, neuroprotectant research, metabolic research,...
UPLIFTEDTM an Optimized Agent of proprietary design developed by the TeamTLR Science comprises three distinct and highly synergistic pathways to afford what may very well be the "Be All, End All" of clean, potent, and rapid-acting antidepressants. A Revolutionary new tool for research into Optimized Antidepressant Efficacy. Research Indications:...
Acetyl Semax (syn. Ac Sem, N-Acetyl Semax, Semax Acetyl) Analogue of Semax demostrated to have markedly superior pharmacodynamics to the parent compound, an agent that demonstrates capacity to stimulate operative memory and attention. Semax has been hypothesized to regulate neurotrophic factors that impart benefits towards neuronal and glial cells.
Optimoterol is an Optimized Agent design to provide the most superior efficacy and therapeutic index for the spectrum of benefits of superior β2 receptor agonist modulation. Research Indications: Anti-Obesity/Lipolytic Research, Anabolic/Myotrophic Research, Neurogenic/Dendritogenic Research, Anti-Aging Research, Mitochondrial Research