Research related to GABA system including agents of the benzodiazepine, barbituate, and alcohol classes, among other classes so related.
Fasoracetam (a.k.a. NS-105 and LAM-105) is a potent HACU-inhibiting, cAMP-modulating, GABAB receptor upregulating/antagonizing, mGluR-modulating, non-monoaminergic anti-depressant nootropic. Research Indications: Nootropic, Antidepressant, Anxiolytic, ADHD Research, Addiction Cessation, GABAergics/Benzodiazepine Research
Flumazenil is a potent benzodiazepine receptor antagonist. Flumazenil administration has been demonstrated to have efficacy to reverse benzodiazepine tolerance and create a facilitation of rapidly alleviating PAWS (Post-Acute Withdrawal Syndrome). Research Indications: Addiction Research, GABAergic/Benzodiazepine Research, Anxiolytic Research
Baclofen as a full agonist at the GABA-B receptor acts as a centrally-acting anxiolytic and skeletal muscle relaxant. As well, it shows efficacy in treatment of alcohol cessation. Research Indications: GABAergic Research, Anxiolytic Research, Addiction Cessation Research